Friday, 24 August 2018

Current Research work Next Generation Sequencing

The HTG EdgeSeq Precision Immuno-Oncology Panel includes applications such as the immunophenotyping of tumor infiltrating lymphocytes (TILs); monitoring of immunotherapy response biomarkers; and the elucidation of immune-escape mechanisms known to drive disease progression. Using only a single 5 ┬Ám formalin-fixed, paraffin-embedded (FFPE) tissue section, the panel profiles 1,392 genes, without the RNA extraction and complex workflow associated with standard RNA-seq methods. Together with the HTG EdgeSeq system, users will have the ability to profile using a wide variety of sample types allowing them to accelerate discovery, support translational applications, and determine potential biomarkers for development of companion diagnostics.

The ability to characterize immune response in tumor environments is believed to be key to developing strategies in recruiting the body's immune system to recognize and respond to the cancer cells. By using the HTG EdgeSeq Precision Immuno-Oncology Panel, researchers can go from raw sample to sequencing-ready libraries in as little as 36 hours, with less than four hours of hands-on time. HTG is also developing analytic modules to provide researchers with the answers they need when they need them and to provide labs with a complete solution to empower precision medicine at the local level.

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